Methyl 1-(1-oxo-6-(4-(4-(trifluoromethyl)benzamido)phenyl)isoindolin-2-yl)cyclobutanecarboxylate → 1-(1-Oxo-6-(4-(4-(trifluoromethyl)benzamido)phenyl)isoindolin-2-yl)cyclo butane carboxylic acid

HRID 404070

반응식

HRID 404070 반응식
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[O:33]=[C:34]1[C:42]2[C:37](=[CH:38][CH:39]=[C:40]([C:43]3[CH:48]=[CH:47][C:46]([NH:49][C:50](=[O:61])[C:51]4[CH:56]=[CH:55][C:54]([C:57]([F:60])([F:59])[F:58])=[CH:53][CH:52]=4)=[CH:45][CH:44]=3)[CH:41]=2)[CH2:36][N:35]1[C:62]1([C:66]([O:68]C)=[O:67])[CH2:65][CH2:64][CH2:63]1>>[O:33]=[C:34]1[C:42]2[C:37](=[CH:38][CH:39]=[C:40]([C:43]3[CH:44]=[CH:45][C:46]([NH:49][C:50](=[O:61])[C:51]4[CH:56]=[CH:55][C:54]([C:57]([F:59])([F:58])[F:60])=[CH:53][CH:52]=4)=[CH:47][CH:48]=3)[CH:41]=2)[CH2:36][N:35]1[C:62]1([C:66]([OH:68])=[O:67])[CH2:65][CH2:64][CH2:63]1

참가 물질

3

반응물 2

HCID 53303003Methyl 1-(1-oxo-6-(4-(4-(trifluoromethyl)benzamido)phenyl)isoindolin-2-yl)cyclobutanecarboxylateHCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid

생성물 1

HCID 673078891-(1-Oxo-6-(4-(4-(trifluoromethyl)benzamido)phenyl)isoindolin-2-yl)cyclo butane carboxylic acid수율 96%

실험 절차

The compound of example 580 was prepared analogous to compound of example 98 by hydrolysis of compound of example 579.

출처 및 근거

ORD 기록
ord-9abd8b42543c4f0087c1d97bf34316e0
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

연결된 노트

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