(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → 1-(6-(4-(4-Methylbenzamido)phenyl)-1-oxoisoindolin-2-yl)cyclobutane carboxylic acid

HRID 404072

반응식

HRID 404072 반응식
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[CH3:33][C:34]1[CH:66]=[CH:65][C:37]([C:38]([NH:40][C:41]2[CH:46]=[CH:45][C:44]([C:47]3[CH:55]=[C:54]4[C:50]([CH2:51][N:52]([C:57]5([C:61]([O:63]C)=[O:62])[CH2:60][CH2:59][CH2:58]5)[C:53]4=[O:56])=[CH:49][CH:48]=3)=[CH:43][CH:42]=2)=[O:39])=[CH:36][CH:35]=1>>[CH3:33][C:34]1[CH:35]=[CH:36][C:37]([C:38]([NH:40][C:41]2[CH:42]=[CH:43][C:44]([C:47]3[CH:55]=[C:54]4[C:50]([CH2:51][N:52]([C:57]5([C:61]([OH:63])=[O:62])[CH2:58][CH2:59][CH2:60]5)[C:53]4=[O:56])=[CH:49][CH:48]=3)=[CH:45][CH:46]=2)=[O:39])=[CH:65][CH:66]=1

참가 물질

3

반응물 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 67307652Methyl 1-(6-(4-(4-methylbenzamido)phenyl)-1-oxoisoindolin-2-yl)cyclobutane carboxylate

생성물 1

HCID 673068301-(6-(4-(4-Methylbenzamido)phenyl)-1-oxoisoindolin-2-yl)cyclobutane carboxylic acid수율 87%

실험 절차

The compound of example 582 was prepared analogous to compound of example 98 by hydrolysis of compound of example 581.

출처 및 근거

ORD 기록
ord-95f731c1ee3b4107b3ffe240d74db8f0
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

연결된 노트

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