Methyl 1-aminocyclopropane-1-carboxylate hydrochloride → Methyl 1-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)cyclopropanecarboxylate

HRID 404073

반응식

HRID 404073 반응식
[CH3:1][CH:2](C)[C@H:3]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:17]3[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=3)=[CH:13][CH:14]=2)[C:9]1=[O:26])[C:4]([O:6][CH3:7])=[O:5].BrCC1C=CC(C2C=CC([N+]([O-])=O)=CC=2)=CC=1C(OC)=O.Cl.NC1(C(OC)=O)CC1>>[N+:23]([C:20]1[CH:21]=[CH:22][C:17]([C:12]2[CH:11]=[C:10]3[C:15]([CH2:16][N:8]([C:3]4([C:4]([O:6][CH3:7])=[O:5])[CH2:2][CH2:1]4)[C:9]3=[O:26])=[CH:14][CH:13]=2)=[CH:18][CH:19]=1)([O-:25])=[O:24]

참가 물질

4

반응물 3

HCID 12760695Methyl 1-aminocyclopropane-1-carboxylate hydrochlorideHCID 67306641Methyl 4-(bromomethyl)-4'-nitrobiphenyl-3-carboxylateHCID 131731440(S)-Methyl 3-methyl-2-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)butanoate

생성물 1

HCID 67313125Methyl 1-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)cyclopropanecarboxylate수율 65%

실험 절차

The compound of example 583 was prepared analogous to compound of example 5 by reaction of compound of example 4 with methyl 1-aminocyclopropanecarboxylate hydrochloride.

출처 및 근거

ORD 기록
ord-20678c9ed6b149ce8a7af55ade3ca7f6
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

연결된 노트

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