methyl (1S,2R)-2-aminocyclopentane-1-carboxylate hydrochloride → HCID 131731583, 화합물

HRID 404078

반응식

HRID 404078 반응식
CC(C)[C@H](N1CC2C(=CC(C3C=CC([N+]([O-])=O)=CC=3)=CC=2)C1=O)C(OC)=O.Br[CH2:29][C:30]1[CH:35]=[CH:34][C:33]([C:36]2[CH:41]=[CH:40][C:39]([N+:42]([O-:44])=[O:43])=[CH:38][CH:37]=2)=[CH:32][C:31]=1[C:45]([O:47]C)=O.Cl.[NH2:50][C@@H:51]1[CH2:55][CH2:54][CH2:53][C@@H:52]1[C:56]([O:58][CH3:59])=[O:57]>>[N+:42]([C:39]1[CH:38]=[CH:37][C:36]([C:33]2[CH:32]=[C:31]3[C:30]([CH2:29][N:50]([C@@H:51]4[CH2:55][CH2:54][CH2:53][C@@H:52]4[C:56]([O:58][CH3:59])=[O:57])[C:45]3=[O:47])=[CH:35][CH:34]=2)=[CH:41][CH:40]=1)([O-:44])=[O:43]

참가 물질

4

반응물 3

HCID 14698816methyl (1S,2R)-2-aminocyclopentane-1-carboxylate hydrochlorideHCID 67306641Methyl 4-(bromomethyl)-4'-nitrobiphenyl-3-carboxylateHCID 131731440(S)-Methyl 3-methyl-2-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)butanoate

생성물 1

HCID 131731583HCID 131731583, 화합물수율 75%

실험 절차

The compound of example 591 was prepared analogous to compound of example 5 by reaction of compound of example 4 with (1S,2R)-methyl 2-aminocyclopentanecarboxylate hydrochloride.

출처 및 근거

ORD 기록
ord-64a77f1865f24e6f9c39636c87b697bc
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

연결된 노트

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