1,2-Dimethyl 4-bromobenzene-1,2-dicarboxylate → (5-Bromo-2-(hydroxymethyl)phenyl)methanol

HRID 404125노트

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HRID 404125 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:12](OC)=[O:13])[C:5](=[CH:10][CH:11]=1)[C:6](OC)=[O:7].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[Br:1][C:2]1[CH:11]=[CH:10][C:5]([CH2:6][OH:7])=[C:4]([CH2:12][OH:13])[CH:3]=1

참가 물질

4

반응물 2

HCID 113232621,2-Dimethyl 4-bromobenzene-1,2-dicarboxylateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 10798791(5-Bromo-2-(hydroxymethyl)phenyl)methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

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온도
0 °C

실험 절차

The compound of example 668 (2 g, 7.326 mmol) was taken in dry THF and was added to a slurry of LiAlH4 (1.67 g, 43.95 mmol) in THF cooled to 0° C. The reaction mixture was stirred at room temperature for 1 h. The reaction mixture was quenched with aqueous NaOH solution followed by extraction with ethyl acetate. The solvent was removed by distillation to afford the title compound.

후처리

  1. customThe reaction mixture was quenched with aqueous NaOH solution
  2. extractionfollowed by extraction with ethyl acetate
  3. customThe solvent was removed by distillation

출처 및 근거

ORD 기록
ord-d8ab5a7b82304f878bd6cd3318476370
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

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