Water → HCID 67307990, 화합물

HRID 404127노트

반응식

HRID 404127 반응식
Br[CH2:2][C:3]1[CH:4]=[C:5]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=2)[CH:6]=[CH:7][C:8]=1[CH2:9]Br.C(=O)([O-])[O-].[K+].[K+].[CH3:26][O:27][C:28](=[O:34])[C@H:29]([CH:31]([CH3:33])[CH3:32])[NH2:30].O>C(#N)C>[CH3:32][CH:31]([CH3:33])[CH:29]([N:30]1[CH2:2][C:3]2[C:8](=[CH:7][CH:6]=[C:5]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=3)[CH:4]=2)[CH2:9]1)[C:28]([O:27][CH3:26])=[O:34]

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 94285Valine methyl esterHCID 673071543,4-bis(Bromomethyl)-4'-nitrobiphenyl

생성물 1

HCID 67307990HCID 67307990, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

The compound of example 671 (3 g, 7.79 mmol) was taken in acetonitrile and to the reaction mixture, potassium carbonate (3.25 g, 23.37 mmol) was added followed by the addition of valine methyl ester (1.56 g, 9.35 mmol). The reaction mixture was refluxed for about 16 h and water was added to quench the reaction. The aqueous mixture was extracted with ethyl acetate to obtain a crude material, which was purified using column chromatography (silicagel, 30% ethyl acetate in petroleum ether).

후처리

  1. additionwas added
  2. temperatureThe reaction mixture was refluxed for about 16 h
  3. customto quench
  4. customthe reaction
  5. extractionThe aqueous mixture was extracted with ethyl acetate

출처 및 근거

ORD 기록
ord-836010156a004d728a8f4cde327f0724
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

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