Phenyl isocyanate → N-{6-Oxo-7-[(triphenylmethyl)sulfanyl]heptyl}-N'-phenylurea

HRID 404204노트

반응식

HRID 404204 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7](=[O:29])[CH2:8][S:9][C:10]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[C:30]1([N:36]=[C:37]=[O:38])[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>ClCCl>[O:29]=[C:7]([CH2:8][S:9][C:10]([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)([C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][NH:1][C:37]([NH:36][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:38]

참가 물질

4

반응물 2

HCID 7672Phenyl isocyanateHCID 670068517-Amino-1-tritylsulfanyl-heptan-2-one

생성물 1

HCID 67006722N-{6-Oxo-7-[(triphenylmethyl)sulfanyl]heptyl}-N'-phenylurea수율 95.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 7-amino-1-tritylsulfanyl-heptan-2-one (0.36 g, 0.86 mmol) in dichloromethane (10 mL) was added phenylisocyanate (0.10 ml, 0.92 mmol). The mixture was stirred at room temperature for 2 h. Solvent was then removed in vacuo and the crude product was purified by column chromatography (dichloromethane/MeOH=100/1 to 40/1) to provide 1-(6-Oxo-7-tritylsulfanyl-heptyl)-3-phenyl-urea (0.43 g, 93%).

후처리

  1. customSolvent was then removed in vacuo
  2. customthe crude product was purified by column chromatography (dichloromethane/MeOH=100/1 to 40/1)

출처 및 근거

ORD 기록
ord-ac919baa8bc74fd19333d201a7f8478b
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748463B2

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