Acetone → 2-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazine

HRID 404404

반응식

HRID 404404 반응식
[N:1]1[C:8](Cl)=[N:7][C:5](Cl)=[N:4][C:2]=1[Cl:3].C([N:12]([CH2:15][CH3:16])[CH2:13][CH3:14])C.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1.CC(C)=[O:25]>O>[Cl:3][C:2]1[N:1]=[C:8]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[N:7]=[C:5]([N:12]2[CH2:13][CH2:14][O:25][CH2:16][CH2:15]2)[N:4]=1

참가 물질

6

반응물 4

HCID 180AcetoneHCID 7954Cyanuric chlorideHCID 8083MorpholineHCID 8471Triethylamine

생성물 1

HCID 2249672-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a stirred solution of cyanuric chloride (18.4 g, 10 mmol) in acetone (100 ml) and crushed ice (500 g), a mixture of triethylamine (30.0 g, excess) and morpholine (17.4 g, 20 mmol) was added at −10° C. After the addition, reaction mixture was stirred at room temperature and for 1 hour and diluted with 50 ml water. Separated white solid was filtered and washed with water. The white solid was dried and filtered. The crude product was found to be pure and taken to next step without purification. Yield: 25 g, 87%; (M+H) 286.7

후처리

  1. additionwas added at −10° C
  2. additionAfter the addition, reaction mixture
  3. customSeparated white solid
  4. filtrationwas filtered
  5. washwashed with water
  6. customThe white solid was dried
  7. filtrationfiltered
  8. customtaken to next step without purification

출처 및 근거

ORD 기록
ord-34c660371fc240228bac8fd8cf0e334a
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748421B2

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