4-(Dimethylamino)Benzaldehyde → n-(5-Carboxypentyl)-4-(4-(dimethylamino)styryl)pyridinium bromide

HRID 40447

반응식

HRID 40447 반응식
[CH3:1][N:2]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]=O)=[CH:6][CH:5]=1)[CH3:3].[Br-:12].[C:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][N+:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1C)([OH:15])=[O:14].N1CCCC[CH2:29]1>C(O)C>[Br-:12].[C:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][N+:21]1[CH:22]=[CH:23][C:24]([CH:29]=[CH:10][C:7]2[CH:6]=[CH:5][C:4]([N:2]([CH3:1])[CH3:3])=[CH:9][CH:8]=2)=[CH:25][CH:26]=1)([OH:15])=[O:14]

참가 물질

5

반응물 3

HCID 74794-(Dimethylamino)BenzaldehydeHCID 8082PiperidineHCID 666435031-(5-Carboxy-pentyl)-2-methyl-pyridinium bromide

생성물 1

HCID 66643380n-(5-Carboxypentyl)-4-(4-(dimethylamino)styryl)pyridinium bromide

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
60 °C

실험 절차

A mixture of 4-N,N-dimethylaminobenzaldehyde (3 g, 20 mmoles), N-(5-carboxy-pentyl)picolinium bromide (5.6 g, 20 mmoles) and piperidine (2 mL) in ethanol (100 mL) was heated at 60° C. overnight. The mixture was evaporated to dryness in vacuo. The residue was redissolved in methanol and then precipitated with ether to give the product (6.7 g).

후처리

  1. customThe mixture was evaporated to dryness in vacuo
  2. dissolutionThe residue was redissolved in methanol
  3. customprecipitated with ether

출처 및 근거

ORD 기록
ord-af6963a81e4745939b0548827d31456a
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530195B2

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