1-Pyrrolidineethanamine → HCID 44546611, 화합물
반응식
[CH:1]12[O:8][CH:5]([CH2:6][CH2:7]1)[CH2:4][N:3]([C:9]1[N:14]=[C:13]([N:15]3[CH2:20][CH2:19][C:18](=O)[CH2:17][CH2:16]3)[N:12]=[C:11]([C:22]3[CH:27]=[CH:26][C:25]([NH:28][C:29]([NH:31][C:32]4[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=4)=[O:30])=[CH:24][CH:23]=3)[N:10]=1)[CH2:2]2.[C:38]([OH:44])([C:40](F)(F)F)=O.[NH2:45][CH2:46][CH2:47]N1CCCC1>>[N:45]1([CH:18]2[CH2:17][CH2:16][N:15]([C:13]3[N:14]=[C:9]([N:3]4[CH2:2][CH:1]5[O:8][CH:5]([CH2:6][CH2:7]5)[CH2:4]4)[N:10]=[C:11]([C:22]4[CH:23]=[CH:24][C:25]([NH:28][C:29]([NH:31][C:32]5[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=5)=[O:30])=[CH:26][CH:27]=4)[N:12]=3)[CH2:20][CH2:19]2)[CH2:40][CH2:38][O:44][CH2:47][CH2:46]1참가 물질
4
실험 절차
By reacting 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-(4-oxopiperidin-1-yl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-4-yl)urea.TFA (50 mg) with 1-(2-aminoethyl)pyrrolidine (0.030 mL) and following the procedure as mentioned in Experimental 118, the title product was isolated as its tri-TFA salt; MS (ES+) 599.8 (M+H)+.
출처 및 근거
- ORD 기록
- ord-bf663baad71a4d77959fe3fd7d7d24d2
- 출처 데이터셋
- uspto-grants-2014_06