2-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazine → 4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)benzonitrile

HRID 404514

반응식

HRID 404514 반응식
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[N:5]=[C:4]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:3]=1.[C:20]([C:22]1[CH:27]=[CH:26][C:25](B(O)O)=[CH:24][CH:23]=1)#[N:21]>>[O:17]1[CH2:18][CH2:19][N:14]([C:4]2[N:5]=[C:6]([N:8]3[CH2:13][CH2:12][O:11][CH2:10][CH2:9]3)[N:7]=[C:2]([C:25]3[CH:26]=[CH:27][C:22]([C:20]#[N:21])=[CH:23][CH:24]=3)[N:3]=2)[CH2:15][CH2:16]1

참가 물질

3

반응물 2

HCID 2249672-Chloro-4,6-bis(morpholin-4-yl)-1,3,5-triazineHCID 27343264-Cyanophenylboronic acid

생성물 1

HCID 585077204-(4,6-Dimorpholino-1,3,5-triazin-2-yl)benzonitrile수율 50%

실험 절차

The title compound was prepared by following the procedure of example 473 step 2 using 4,4′-(6-chloro-1,3,5-triazine-2,4-diyl)dimorpholine and 4-cyanophenyl-boronic acid. Yield 86 mg, 50% yield; HPLC: Rt=2.60 min; MS 353 [M+H].

출처 및 근거

ORD 기록
ord-e8c283c2704a4069a50628c089ea924e
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748421B2

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