Tributylamine → Emtricitabine

HRID 404538노트

반응식

HRID 404538 반응식
C(N(CCCC)CCCC)CCC.[CH2:14]1[S:18][C@H:17]([CH2:19][OH:20])[O:16][C@@H:15]1[N:21]1[C:26](=[O:27])[N:25]=[C:24]([NH2:28])[C:23]([F:29])=[CH:22]1.Cl>ClCCl>[CH2:14]1[S:18][C@H:17]([CH2:19][OH:20])[O:16][C@@H:15]1[N:21]1[C:26](=[O:27])[N:25]=[C:24]([NH2:28])[C:23]([F:29])=[CH:22]1

참가 물질

4

반응물 2

HCID 7622TributylamineHCID 53311196HCID 53311196, 화합물

생성물 1

HCID 60877Emtricitabine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Tri-n-butyl amine (76.76 g) was added to a solution of emtricitabine hydrochloride (101 g; Example 3) in dichloromethane (450 mL) in 30 minutes at 25° C. to 30° C. The solution was stirred at 25° C. to 30° C. for about 5 hours. The product was filtered, washed with dichloromethane (112.5 mL) and dried under vacuum at 40° C. to 45° C. for about 14 hours.

후처리

  1. filtrationThe product was filtered
  2. washwashed with dichloromethane (112.5 mL)
  3. customdried under vacuum at 40° C. to 45° C. for about 14 hours

출처 및 근거

ORD 기록
ord-e63f11ac20784170855bf445f6bd8b86
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748604B2

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