Piperidine → 2-(4-Chlorophenyl)-2-(piperidin-1-YL)acetic acid

HRID 404678노트

반응식

HRID 404678 반응식
Br[CH:2]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)[C:3]([OH:5])=[O:4].[NH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1>C(#N)C>[Cl:12][C:9]1[CH:10]=[CH:11][C:6]([CH:2]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[C:3]([OH:5])=[O:4])=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 10490868alpha-Bromo-4-chlorophenylacetic acid

생성물 1

HCID 162439412-(4-Chlorophenyl)-2-(piperidin-1-YL)acetic acid수율 62.4%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

2-Bromo-2-(4-chlorophenyl)acetic acid (300 mg, 1.20 mmol), piperidine (125 μl, 1.26 mmol) and TEA (503 μl, 3.61 mmol) were dissolved in acetonitrile (6 ml). The resulting reaction was stirred at room temperature for 48 hours. Acetonitrile was evaporated, the residue was triturated with acetonitrile/petroleum ether (9/1) and filtered by suction filtration to collect 2-(4-chlorophenyl)-2-(piperidin-1-yl)acetic acid (190 mg, 62.3% yield) as a white solid.

후처리

  1. customThe resulting reaction
  2. customAcetonitrile was evaporated
  3. customthe residue was triturated with acetonitrile/petroleum ether (9/1)
  4. filtrationfiltered by suction filtration

출처 및 근거

ORD 기록
ord-5b67af9bf40c45e49f31644160a14fbd
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748613B2

반응 노트

불러오는 중…