6-Bromoisoquinoline → 6-Bromo-7-chloroisoquinoline

HRID 404722노트

반응식

HRID 404722 반응식
[Br:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]([CH2:18][CH:19](OC)OC)S(C2C=CC(C)=CC=2)(=O)=O)=[CH:4][C:3]=1[Cl:26].BrC1C=C2C(=CC=1)C=NC=C2>>[Br:1][C:2]1[CH:25]=[C:24]2[C:5](=[CH:4][C:3]=1[Cl:26])[CH:6]=[N:7][CH:18]=[CH:19]2

참가 물질

3

반응물 2

HCID 3136816-BromoisoquinolineHCID 59226258N-(4-Bromo-3-chloro-benzyl)-N-(2,2-dimethoxy-ethyl)-4-methyl-benzene-sulfonamide

생성물 1

HCID 534186156-Bromo-7-chloroisoquinoline

실험 절차

Starting from N-(4-Bromo-3-chloro-benzyl)-N-(2,2-dimethoxy-ethyl)-4-methyl-benzene-sulfonamide (8), the title compound was synthesized by the protocol described for 6-Bromo-isoquinoline (3). Rt=1.02 min (Method C). Detected mass: 242.2/244.2 (M+H+).

출처 및 근거

ORD 기록
ord-cc2e12a130074f5e8192947096254916
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748614B2

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