6-Bromo-7-chloroisoquinoline → (Rac)-6-(azepan-4-ylsulfanyl)-7-chloro-isoquinoline hydrochloride
반응식
BrC1C=C2C(=CC=1[Cl:12])C=NC=C2.[NH:13]1[CH2:19][CH2:18][CH2:17][CH:16]([S:20][C:21]2[CH:22]=[C:23]3[C:28](=[CH:29][C:30]=2[Cl:31])[CH:27]=[N:26][CH:25]=[CH:24]3)[CH2:15][CH2:14]1.C(OC(N1CCCC(O)CC1)=O)(C)(C)C>>[ClH:12].[NH:13]1[CH2:19][CH2:18][CH2:17][CH:16]([S:20][C:21]2[CH:22]=[C:23]3[C:28](=[CH:29][C:30]=2[Cl:31])[CH:27]=[N:26][CH:25]=[CH:24]3)[CH2:15][CH2:14]1참가 물질
3
실험 절차
Starting from 6-Fluoro-7-chloroisoquinoline (263) and 4-Hydroxy-azepane-1-carboxylic acid tert-butyl ester (Rac)-6-(Azepan-4-ylsulfanyl)-7-chloro-isoquinoline could be obtained as the hydrochloride as described for compound (268). Rt=0.83 min (Method B). Detected mass: 293.1/295.1 (M+H+).
출처 및 근거
- ORD 기록
- ord-dec60f9e7a364253bf670b0408b25352
- 출처 데이터셋
- uspto-grants-2014_06