참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4,6-Dichloropyrimidine | HCID 70943 | — |
| 반응물 | tert-butyl N-(3-aminophenyl)carbamate | HCID 12877220 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Tert-butyl 3-(6-chloropyrimidin-4-ylamino)phenylcarbamate | HCID 57708283 | — |
반응 단계
4,6-Dichloropyrimidine (1.5 g, 10 mmol), tert-butyl 3-aminophenylcarbamate (2.1 g, 10 mmol) and triethylamine (2.2 g, 20 mmol) were mixed in ethanol (20 mL), heated at 80° C. for 16 hr. The reaction mixture was cooled to RT and solvent was removed in vacuo. The gummy crude product was mixed with 20 mL of DCM and was stirred at RT to give an off-white solid, which was filtered and dried under vacuum (1.6 g, 5 mmol). MS (m/z): MH+=321, 323.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08748606B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_06 |
|---|
| ORD ID | ord-224bfa23e9db4f3aa6f1aca4bfb637f7 |
|---|
| 출처 메모 | uspto-grants-2014_06 |
|---|
