Benzothiazolone → 3-[4-(2-Oxobenzothiazol-3-ylmethoxy)-phenyl]hex-4-ynoic acid

HRID 40488

반응식

[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]1=[O:10].[C:11](OCI)(=O)C(C)(C)C.[OH:20][C:21]1[CH:26]=[CH:25][C:24]([CH:27]([C:33]#[C:34][CH3:35])[CH2:28][C:29]([O:31]C)=[O:30])=[CH:23][CH:22]=1>>[O:10]=[C:2]1[N:3]([CH2:11][O:20][C:21]2[CH:26]=[CH:25][C:24]([CH:27]([C:33]#[C:34][CH3:35])[CH2:28][C:29]([OH:31])=[O:30])=[CH:23][CH:22]=2)[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[S:1]1

참가 물질

반응물 3

HCID 13625Benzothiazolone

HCID 104401Iodomethyl pivalate

HCID 57835749Methyl 3-(4-hydroxyphenyl)hex-4-ynoate

생성물 1

HCID 547554453-[4-(2-Oxobenzothiazol-3-ylmethoxy)-phenyl]hex-4-ynoic acid

실험 절차

Analogously to example 6, 3H-benzothiazol-2-one, iodomethyl pivalate and methyl 3-(4-hydroxyphenyl)hex-4-ynoate were used to obtain 3-[4-(2-oxobenzothiazol-3-ylmethoxy)-phenyl]hex-4-ynoic acid.

출처 및 근거

ORD 기록: ord-9dce468465bd408db8044e09cd781334
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08530413B2

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