Methanol → HCID 13523632, 화합물

HRID 404997노트

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HRID 404997 반응식
[CH2:1]([O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C@H:2]1[O:4][CH2:3]1.[OH-:13].[K+].[CH3:15]O>>[CH2:6]([O:5][CH2:1][C@@H:2]([OH:4])[CH2:3][O:13][CH3:15])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 146296(+)-Benzyl glycidyl ether

생성물 1

HCID 13523632HCID 13523632, 화합물수율 98%

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온도
30 °C

실험 절차

To a stirred solution of (S)-benzyl glycidyl ether (S)-2 (4 g, 24.3 mmol) in methanol (40 mL) was added slowly a powdered KOH (4 g; 70 mmol) at 10° C. and the reaction mixture was stirred at 30° C. temperature for 8 h, after which the solvent was evaporated under reduced pressure. The residue was dissolved in ethylacetate (50 mL), washed with water, dried over Na2SO4, and evaporated under reduced pressure. The crude product was purified by column chromatography (silica gel, petroleum ether/acetone, 90:10) to afford (S)-1-(benzyloxy)-3-methoxypropan-2-ol (S)-3 as a colorless oil (4.6 g, 98%).

후처리

  1. customafter which the solvent was evaporated under reduced pressure
  2. dissolutionThe residue was dissolved in ethylacetate (50 mL)
  3. washwashed with water
  4. dry with materialdried over Na2SO4
  5. customevaporated under reduced pressure
  6. customThe crude product was purified by column chromatography (silica gel, petroleum ether/acetone, 90:10)

출처 및 근거

ORD 기록
ord-a69777300fac424d92d4b661eeeee5c1
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748660B2

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