Potassium Carbonate → 4-(4-Cyclohexylphenoxy)-2,5-dimethylnitrobenzene

HRID 405005

반응식

HRID 405005 반응식
[CH:1]1([C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[C:15]1[C:20]([CH3:21])=[CH:19][C:18]([N+:22]([O-:24])=[O:23])=[C:17]([CH3:25])[CH:16]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH:1]1([C:7]2[CH:8]=[CH:9][C:10]([O:13][C:15]3[C:20]([CH3:21])=[CH:19][C:18]([N+:22]([O-:24])=[O:23])=[C:17]([CH3:25])[CH:16]=3)=[CH:11][CH:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 143274-CyclohexylphenolHCID 2527931-Chloro-2,5-dimethyl-4-nitrobenzene

생성물 1

HCID 685962084-(4-Cyclohexylphenoxy)-2,5-dimethylnitrobenzene수율 88.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
150 °C

실험 절차

5.81 g (33.0 mmol) of 4-cyclohexylphenol, 5.57 g (30.0 mmol) of 4-chloro-2,5-dimethylnitrobenzene and 6.22 g (45.0 mmol) of potassium carbonate are suspended in 30 ml of N,N-dimethylformamide and the suspension is stirred at 150° C. for 12 h. It is then poured into ice-water and the precipitate is isolated by filtration, washed repeatedly with hexane and dried under reduced pressure (12.1 g, purity 71.9%, yield 88.9%, log P (pH 2.3)=6.69).

후처리

  1. customthe precipitate is isolated by filtration
  2. washwashed repeatedly with hexane
  3. customdried under reduced pressure (12.1 g, purity 71.9%, yield 88.9%, log P (pH 2.3)=6.69)

출처 및 근거

ORD 기록
ord-4854bb2d5d8d4c8f93cf2c2d092418ca
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748662B2

연결된 노트

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