(S)-N-(1-{4-[3-(4-Benzyloxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide → HCID 86689006, 화합물

HRID 40501노트

반응식

HRID 40501 반응식
C([O:8][C:9]1[CH:31]=[CH:30][C:12]([O:13][CH:14]2[CH2:17][N:16]([C:18]3[CH:23]=[CH:22][C:21]([C@@H:24]([NH:26][C:27](=[O:29])[CH3:28])[CH3:25])=[CH:20][CH:19]=3)[CH2:15]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([O:13][CH:14]2[CH2:15][N:16]([C:18]3[CH:23]=[CH:22][C:21]([C@@H:24]([NH:26][C:27](=[O:29])[CH3:28])[CH3:25])=[CH:20][CH:19]=3)[CH2:17]2)=[CH:30][CH:31]=1

참가 물질

4

반응물 1

HCID 86689007(S)-N-(1-{4-[3-(4-Benzyloxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide

생성물 1

HCID 86689006HCID 86689006, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

1.3 g (3.12 mmol) (S)—N-(1-{4-[3-(4-Benzyloxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide (Ex. 8.5) and 130 mg Pd/C (10%) in 50 mL MeOH are hydrogenated at 3 bar and 50° C. for 12 h. The mixture is filtered and concentrated in vacuo. The residue is titurated with diisopropyl ether to yield the desired product.

후처리

  1. filtrationThe mixture is filtered
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-0ac63658c6ee4e2187ecb779868332df
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530461B2

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