Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → Ethyl 3-(5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)amino)methyl)phenyl)picolinamido)propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | 4-Amino-4'-chlorodiphenyl | HCID 8675 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | Ethyl 3-(5-(5-chloro-2-formylphenyl)picolinamido)propanoate | HCID 86674246 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Ethyl 3-(5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)amino)methyl)phenyl)picolinamido)propanoate | HCID 71059834 | — |
반응 단계
Solid NaBH(OAc)3 (388 mg, 1.83 mmol) was added to a DCE solution (2 mL) of ethyl 3-(5-(5-chloro-2-formylphenyl)picolinamido)propanoate (330 mg, 0.92 mmol), 4′-chloro-[1,1′-biphenyl]-4-amine (186 mg, 0.92 mmol), and AcOH (0.21 mL, 3.66 mmol) and the resulting mixture was stirred at room temperature. After 16 h the resulting mixture diluted with EtOAc washed with water and brine, dried (Na2SO4), dry-packed onto silica gel and purified via column chromatography to yield the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08748624B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-d762f74b1e1445fca55096b2d0257abb |
| 출처 메모 | uspto-grants-2014_06 |