Boron tribromide → HCID 86674268, 화합물
반응식
B(Br)(Br)Br.[Cl:5][C:6]1[C:7]([C:16]([F:19])([F:18])[F:17])=[CH:8][C:9]([O:14]C)=[C:10]([CH:13]=1)[CH:11]=[O:12]>C(Cl)Cl>[Cl:5][C:6]1[C:7]([C:16]([F:17])([F:18])[F:19])=[CH:8][C:9]([OH:14])=[C:10]([CH:13]=1)[CH:11]=[O:12]참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
A 1M DCM solution of BBr3 (24.0 mL, 24.0 mmol) was added to neat 5-chloro-2-methoxy-4-(trifluoromethyl)benzaldehyde (3.4 g, 14.4 mmol) and the resulting mixture was heated to 50° C. After 1 h the resulting mixture was diluted with DCM and ice and the layers were separated. The aqueous phase was added was extracted with DCM and the combined organics were dried (Na2SO4), concentrated and purified via column chromatography to yield the title compound.
후처리
- customthe layers were separated
- additionThe aqueous phase was added
- extractionwas extracted with DCM
- dry with materialthe combined organics were dried (Na2SO4)
- concentrationconcentrated
- custompurified via column chromatography
출처 및 근거
- ORD 기록
- ord-e2f177fa195a4d14adf31e690d64a582
- 출처 데이터셋
- uspto-grants-2014_06
- 특허 번호
- US08748624B2
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