Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dichloroethane → 2-bromo-N-(4'-chloro-[1,1'-biphenyl]-4-yl)-4-methylbenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dichloroethane | HCID 11 | — |
| 반응물 | 4-Amino-4'-chlorodiphenyl | HCID 8675 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-Bromo-4-methylbenzoic acid | HCID 226292 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-bromo-N-(4'-chloro-[1,1'-biphenyl]-4-yl)-4-methylbenzamide | HCID 71060083 | — |
반응 단계
4′-chloro-[1,1′-biphenyl]-4-amine (159 mg, 0.78 mmol), 2-bromo-4-methylbenzoic acid (140 mg, 0.65 mmol), EDC (125 mg, 0.65 mmol), HOBt (100 mg, 0.65 mmol), and diisopropylethyl amine (0.22 mL, 1.30 mmol) were dissolved in THF (2.6 mL) and stirred at room temperature. After 3 h the resulting mixture directly purified via column chromatography to yield the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08748624B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-5c7d59f64ce94b76a6e62c06cf8ab6b8 |
| 출처 메모 | uspto-grants-2014_06 |