1,2-Dichloroethane → 2-bromo-N-(4'-chloro-[1,1'-biphenyl]-4-yl)-4-methylbenzamide

HRID 405220

반응식

HRID 405220 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[Br:15][C:16]1[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][C:17]=1[C:18](O)=[O:19].C(Cl)CCl.C1C=CC2N(O)N=NC=2C=1.C(N(C(C)C)CC)(C)C>C1COCC1>[Br:15][C:16]1[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][C:17]=1[C:18]([NH:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)=[CH:9][CH:10]=1)=[O:19]

참가 물질

7

반응물 5

HCID 111,2-DichloroethaneHCID 86754-Amino-4'-chlorodiphenylHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 2262922-Bromo-4-methylbenzoic acid

생성물 1

HCID 710600832-bromo-N-(4'-chloro-[1,1'-biphenyl]-4-yl)-4-methylbenzamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

4′-chloro-[1,1′-biphenyl]-4-amine (159 mg, 0.78 mmol), 2-bromo-4-methylbenzoic acid (140 mg, 0.65 mmol), EDC (125 mg, 0.65 mmol), HOBt (100 mg, 0.65 mmol), and diisopropylethyl amine (0.22 mL, 1.30 mmol) were dissolved in THF (2.6 mL) and stirred at room temperature. After 3 h the resulting mixture directly purified via column chromatography to yield the title compound.

후처리

  1. customAfter 3 h the resulting mixture directly purified via column chromatography

출처 및 근거

ORD 기록
ord-5c7d59f64ce94b76a6e62c06cf8ab6b8
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748624B2

연결된 노트

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