Triethylamine → N-(1-(2-bromo-4-chlorophenyl)ethyl)-4'-fluoro-[1,1'-biphenyl]-4-amine

HRID 405235노트

반응식

HRID 405235 반응식
CS(Cl)(=O)=O.[Br:6][C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:8]=1[CH:14](O)[CH3:15].CCN(CC)CC.[F:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]2[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][CH:32]=2)=[CH:27][CH:26]=1>C(Cl)Cl>[Br:6][C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:8]=1[CH:14]([NH:37][C:34]1[CH:33]=[CH:32][C:31]([C:28]2[CH:29]=[CH:30][C:25]([F:24])=[CH:26][CH:27]=2)=[CH:36][CH:35]=1)[CH3:15]

참가 물질

6

반응물 4

HCID 8471Triethylamine2회HCID 94624'-Fluoro(1,1'-biphenyl)-4-amineHCID 31297Methanesulfonyl chlorideHCID 574450731-(2-Bromo-4-chlorophenyl)ethanol

생성물 1

HCID 71060075N-(1-(2-bromo-4-chlorophenyl)ethyl)-4'-fluoro-[1,1'-biphenyl]-4-amine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Neat methanesulfonyl chloride (0.18 mL, 2.4 mmol) was added to a 0° C., DCM solution (20 mL) of 1-(2-bromo-4-chlorophenyl)ethanol (558 mg, 2.4 mmol) and Et3N (0.36 mL, 2.6 mmol) and the resulting mixture was allowed to warm to room temperature gradually. After 30 min Et3N (0.36 mL, 2.6 mmol) and 4′-fluoro-[1,1′-biphenyl]-4-amine (444 g, 2.4 mmol) were added sequentially and stirred at room temperature. After 16 h the resulting mixture was concentrated and purified via column chromatography to yield the title compound.

후처리

  1. concentrationAfter 16 h the resulting mixture was concentrated
  2. custompurified via column chromatography

출처 및 근거

ORD 기록
ord-caeff1b21d554846b9dfa00a271a2c41
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748624B2

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