Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 40526생성일: 2026년 10월 24일
Sodium hydride → (S)-N-(1-{4-[3-(2-Cyclopropylmethoxy-pyridin-4-yloxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide
https://huagongshe.com/ko/reaction/40526
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Cyclopropanemethanol | HCID 75644 | — |
| 반응물 | (S)-N-(1-{4-[3-(2-Fluoro-pyridin-4-yloxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide | HCID 86689013 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | (S)-N-(1-{4-[3-(2-Cyclopropylmethoxy-pyridin-4-yloxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide | HCID 86689027 | — |
반응 단계
To 55 mg (0.17 mmol) (S)—N-(1-{4-[3-(2-Fluoro-pyridin-4-yloxy)-azetidin-1-yl]-phenyl}-ethyl)-acetamide (XI.1) in 5 mL 1,4-dioxane is added 0.14 mL (1.73 mmol) cyclopropanemethanol. 38 mg (0.95 mmol, 60% suspension in mineral oil) NaH is added and the mixture is stirred for 15 h at 130° C. After concentration in vacuo the residue is purified by chormotography (silica, ethylacetate) to yield the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08530461B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
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| ORD ID | ord-a056d0b03c8f4f7e94bd433ec3b60523 |
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| 출처 메모 | uspto-grants-2013_09 |
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