Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → Hydroxyamfetamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 4-Hydroxyphenylacetone | HCID 7019274 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Hydroxyamfetamine | HCID 3651 | — |
반응 단계
A mixture of 7.00 g (46.6 mmol) 4-hydroxyphenylacetone and 200 mL 7N ammonia in MeOH is charged with 0.70 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (50 psi) at r.t. over night. After complete reaction, the mixture is filtrated, the solvent is removed in vacuo and the crude product is purified by HPLC (MeOH/H2O/NH3).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08530460B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-cb14c09e723444f6967e7938a6ec22f0 |
| 출처 메모 | uspto-grants-2013_09 |