Ammonia → Hydroxyamfetamine

HRID 40556

반응식

HRID 40556 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=O)[CH3:10])=[CH:4][CH:3]=1.[NH3:12].[H][H]>CO.[Ni]>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([NH2:12])[CH3:10])=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 222AmmoniaHCID 70192744-HydroxyphenylacetoneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 3651Hydroxyamfetamine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

A mixture of 7.00 g (46.6 mmol) 4-hydroxyphenylacetone and 200 mL 7N ammonia in MeOH is charged with 0.70 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (50 psi) at r.t. over night. After complete reaction, the mixture is filtrated, the solvent is removed in vacuo and the crude product is purified by HPLC (MeOH/H2O/NH3).

후처리

  1. customAfter complete reaction
  2. filtrationthe mixture is filtrated
  3. customthe solvent is removed in vacuo
  4. customthe crude product is purified by HPLC (MeOH/H2O/NH3)

출처 및 근거

ORD 기록
ord-cb14c09e723444f6967e7938a6ec22f0
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530460B2

연결된 노트

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