Dimethylformamide → 1-Bromo-4-(cyclopropylmethoxy)benzene
반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl[CH2:10][CH:11]1[CH2:13][CH2:12]1.C([O-])([O-])=O.[K+].[K+].CN(C=O)C>O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][CH:11]2[CH2:13][CH2:12]2)=[CH:4][CH:3]=1참가 물질
6
반응 조건
- 온도
- 80 °C
실험 절차
5.0 g (28.9 mmol) 4-bromophenol, 3.93 g (43.4 mmol) (chloromethyl)cyclopropane and 7.99 g (57.8 mmol) K2CO3 are added to 10 mL DMF and stirred at 80° C. over night. Afterwards the reaction mixture is diluted with water and extracted with DCM. The organic layer is dried with MgSO4 and the solvent is removed in vacuo.
후처리
- extractionextracted with DCM
- dry with materialThe organic layer is dried with MgSO4
- customthe solvent is removed in vacuo
출처 및 근거
- ORD 기록
- ord-2949511e5a7443a78404720baec74d54
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08530460B2
반응 노트
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