Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Bromide → 2-Bromo-5-ethoxypyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Bromide | HCID 6332 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Bromo-5-hydroxypyridine | HCID 2762865 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-Bromo-5-ethoxypyridine | HCID 23436892 | — |
반응 단계
2.51 g (22.99 mmol) 1-bromoethane and 1.99 g (14.37 mmol) K2CO3 are added to a mixture of 1.0 g (5.75 mmol) 2-bromo-5-hydroxypyridine in 100 mL ACN. The mixture is stirred at reflux over night. Then the reaction mixture is poured onto water and extracted with TBME. The organic layer is dried with Na2SO4 and the solvent is removed under vacuo. The residue is purified by column chromatography (silica gel, PE/EtOAC 1/1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08530460B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-52b68b2543574d2f8bafa4e5182d8539 |
| 출처 메모 | uspto-grants-2013_09 |