Ammonia → 4-Isopropoxy-3-thioureidobenzenesulfonamide

HRID 405674노트

반응식

HRID 405674 반응식
[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH2:14])(=[O:13])=[O:12])=[CH:7][C:6]=1[N:15]=[C:16]=[S:17])([CH3:3])[CH3:2].[NH3:18]>CO>[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH2:14])(=[O:13])=[O:12])=[CH:7][C:6]=1[NH:15][C:16]([NH2:18])=[S:17])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 866653704-Isopropoxy-3-isothiocyanato-benzenesulfonamide

생성물 1

HCID 866655834-Isopropoxy-3-thioureidobenzenesulfonamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Crude 4-isopropoxy-3-isothiocyanato-benzenesulfonamide (17.8 g, 65.2 mmol, example 2, step e) was treated with a 2 M solution of ammonia in MeOH (250 mL) and the resulting solution was stirred at room temperature for 18 h. The reaction mixture was then concentrated to about half the volume until a large amount of tan solid precipitated. The suspension was cooled to 0° C. for 30 minutes and was filtered. The solid was washed with methanol and ether to give the title compound as a cream colored solid.

후처리

  1. concentrationThe reaction mixture was then concentrated to about half the volume until a large amount of tan solid
  2. customprecipitated
  3. temperatureThe suspension was cooled to 0° C. for 30 minutes
  4. filtrationwas filtered
  5. washThe solid was washed with methanol and ether

출처 및 근거

ORD 기록
ord-0f5602def9e44f86b5b52862fec149a9
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08753857B2

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