Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid → 2-Methyl-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid | HCID 606540 | — |
| 반응물 | (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine | HCID 86672004 | — |
| 생성물 | 2-Methyl-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide | HCID 66558854 | — |
반응 단계
The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate A8.2) and 2-methyl-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (CAS 128694-63-3) following procedure I yielded the title compound as a white solid. MS (ISP): m/z=418.3 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08754075B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-c77191b856784cafac7ff5ec9c797fae |
| 출처 메모 | uspto-grants-2014_06 |