5-Bromo-4-fluoro-2-methylaniline → 5-Amino-2-fluoro-4-methylbenzonitrile
반응식
Br[C:2]1[C:3]([F:10])=[CH:4][C:5]([CH3:9])=[C:6]([CH:8]=1)[NH2:7].[C:11]([Cu])#[N:12]>CN1C(=O)CCC1.[Cu]I>[NH2:7][C:6]1[C:5]([CH3:9])=[CH:4][C:3]([F:10])=[C:2]([CH:8]=1)[C:11]#[N:12]참가 물질
5
반응 조건
- 온도
- 195 °C
실험 절차
A mixture of 5-bromo-4-fluoro-2-methylaniline (2.04 g, 10.0 mmol), CuCN (889 mg, 10.0 mmol) and CuI (1.9 g, 10.0 mmol) in NMP was purged with N2 for 5 minutes and then sealed and heated at 195° C. for 30 minutes under microwave condition. The mixture was subjected to standard aqueous workup to give a residue which was purified by silica chromatography to yield 5-amino-2-fluoro-4-methylbenzonitrile (51) (540 mg, 36% yield). MS m/z 151.0 (M+1)+.
후처리
- customwas purged with N2 for 5 minutes
- customsealed
- customto give a residue which
- customwas purified by silica chromatography
출처 및 근거
- ORD 기록
- ord-b2064c9d8a294fa5b052e6e3f4e86f91
- 출처 데이터셋
- uspto-grants-2014_06
- 특허 번호
- US08754071B2
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