Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
n-Methyl-3-nitropyridin-4-amine → 4-N-methylpyridine-3,4-diamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | n-Methyl-3-nitropyridin-4-amine | HCID 556016 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-N-methylpyridine-3,4-diamine | HCID 910412 | 83.8% |
반응 단계
2.3 g methyl-(3-nitropyridin-4-yl)-amine are hydrogenated in 50 ml of methanol for and with 0.8 g Raney nickel for 2.5 h at 50° C. and 50 psi hydrogen pressure. The catalyst is filtered off and the filtrate is evaporated to dryness. The product is purified by chromatography (Alox, dichloromethane/methanol from 99/1 to 19/1). 1.55 g product are obtained as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08754073B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-15a1784810ef4e29b7c08e8f34ae74ca |
| 출처 메모 | uspto-grants-2014_06 |