2,4-Difluoronitrobenzene → HCID 58421532, 화합물

HRID 406059노트

반응식

HRID 406059 반응식
[CH3:1][C:2]([O:5][C:6]([NH:8][C@@H:9]1[C@@H:13]([OH:14])[CH2:12][CH2:11][CH2:10]1)=[O:7])([CH3:4])[CH3:3].[Li+].C[Si]([N-][Si](C)(C)C)(C)C.F[C:26]1[CH:31]=[C:30]([F:32])[CH:29]=[CH:28][C:27]=1[N+:33]([O-:35])=[O:34]>C1COCC1.O>[C:2]([O:5][C:6](=[O:7])[NH:8][C@H:9]1[CH2:10][CH2:11][CH2:12][C@@H:13]1[O:14][C:26]1[CH:31]=[C:30]([F:32])[CH:29]=[CH:28][C:27]=1[N+:33]([O-:35])=[O:34])([CH3:1])([CH3:3])[CH3:4]

참가 물질

6

반응물 3

HCID 679672,4-DifluoronitrobenzeneHCID 2733832Lithium HexamethyldisilazideHCID 10104271tert-Butyl [(1S,2S)-2-hydroxycyclopentyl]carbamate

생성물 1

HCID 58421532HCID 58421532, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
10 °C

실험 절차

(1S,2S)-trans-N-boc-2-aminocyclopentanol was dissolved in 50 ml THF and cooled to 10° C. To the reaction mixture were added 32.2 ml LiHMDS 1M in THF. After 1 hour 2.72 ml 2,4-difluoronitrobenzol were added and the mixture was stirred at rt overnight. Then the mixture was poured in water and extracted with ethylacetate. The organic layer was washed with water, dried and concentrated in vacuo.

후처리

  1. extractionextracted with ethylacetate
  2. washThe organic layer was washed with water
  3. customdried
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-12a2ae7edcfd47aeb5df371811bec19e
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754079B2

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