3-Bromobenzaldehyde → 4-(3-Bromo-benzyl)-piperazine-1-carboxylic acid phenylamide

반응식

[C:1]1([NH:7][C:8]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=1)[CH:20]=O>>[C:1]1([NH:7][C:8]([N:10]2[CH2:15][CH2:14][N:13]([CH2:20][C:19]3[CH:22]=[CH:23][CH:24]=[C:17]([Br:16])[CH:18]=3)[CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

반응물 2

HCID 765833-Bromobenzaldehyde

HCID 7015289N-phenylpiperazine-1-carboxamide

생성물 1

HCID 171851254-(3-Bromo-benzyl)-piperazine-1-carboxylic acid phenylamide

실험 절차

The title compound was prepared from piperazine-1-carboxylic acid phenylamide and 3-bromobenzaldehyde. 1H NMR (400 MHz, CDCl3): 7.50 (br s, 1H), 7.43-7.17 (m, 7H), 7.05-7.00 (m, 1H), 6.47 (br s, 1H), 3.52-3.45 (m, 6H), 2.48-2.42 (m, 4H).

출처 및 근거

ORD 기록: ord-be19c54a6a7b4363ad6e79a44808b534
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08530476B2

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