Phenyl isocyanate → 4-benzyl-N-phenylpiperidine-1-carboxamide

반응식

[CH2:1]([CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:14]1([N:20]=[C:21]=[O:22])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[C:14]1([NH:20][C:21]([N:11]2[CH2:12][CH2:13][CH:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[CH2:9][CH2:10]2)=[O:22])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

반응물 2

HCID 7672Phenyl isocyanate

HCID 317384-Benzylpiperidine

생성물 1

HCID 50647624-benzyl-N-phenylpiperidine-1-carboxamide

실험 절차

The title compound was prepared from 4-benzylpiperidine and phenyl isocyanate. 1H NMR (400 MHz, CDCl3): 7.35-7.10 (m, 9H), 7.02-6.97 (m, 1H), 6.50 (br s, 1H), 4.07-4.00 (m, 2H), 2.77 (td, J=13, 2.4 Hz, 2H), 2.54 (d, J=6.8 Hz, 2H), 1.76-1.64 (m, 3H), 1.28-1.15 (m, 2H).

출처 및 근거

ORD 기록: ord-08d70f8136dc4358a3f4f47709fcca4e
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08530476B2

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