Benzenepropanal → 4-(3-Phenyl-propyl)-piperazine-1-carboxylic acid phenylamide

반응식

[C:1]1([NH:7][C:8]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:16]1([CH2:22][CH2:23][CH:24]=O)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:1]1([NH:7][C:8]([N:10]2[CH2:15][CH2:14][N:13]([CH2:24][CH2:23][CH2:22][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

반응물 2

HCID 7707Benzenepropanal

HCID 7015289N-phenylpiperazine-1-carboxamide

생성물 1

HCID 578808544-(3-Phenyl-propyl)-piperazine-1-carboxylic acid phenylamide

실험 절차

The title compound was prepared from piperazine-1-carboxylic acid phenylamide and 3-phenylpropionaldehyde. 1H NMR (400 MHz, CDCl3): 7.36-7.16 (m, 9H), 7.05-7.00 (m, 1H), 6.40 (br s, 1H), 3.52-3.47 (m, 4H), 2.65 (t, J=7.6 Hz, 2H), 2.47-2.38 (m, 4H), 2.39 (t, J=7.4 Hz, 2H), 1.88-1.79 (m, 2H).

출처 및 근거

ORD 기록: ord-857e29d418ab43849cad5899dff67de5
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08530476B2

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