Trimethylsilyldiazomethane → Methyl 6-ureidohexanoate

HRID 406300

반응식

HRID 406300 반응식
[NH:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[C:2]([NH2:4])=[O:3].[CH3:13][Si](C=[N+]=[N-])(C)C>CO.C1C=CC=CC=1>[NH:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])[C:2]([NH2:4])=[O:3]

참가 물질

4

반응물 2

HCID 167693TrimethylsilyldiazomethaneHCID 4605066-Ureidohexanoic acid

생성물 1

HCID 43406503Methyl 6-ureidohexanoate

시약·촉매·용매 1

HCID 21927730Benzene methanol용매

실험 절차

A solution of 6-ureidohexanoic acid (0.996 g, 5.72 mmol, 1.0 equiv) in methanol/benzene (2:7, 60 mL) was cooled to 0 degrees C., and a solution of trimethylsilyldiazomethane in hexanes (2.0 M, 3.43 mL, 6.86 mmol, 1.2 equiv) was added. The reaction mixture was warmed to room temperature and stirred for 1 h prior to removing all volatile components in vacuo. The crude methyl ester (1.06 g, 5.61 mmol, 98%) was used without further purification in the Biginelli reaction.

후처리

  1. customto removing all volatile components in vacuo

출처 및 근거

ORD 기록
ord-6de01cca02474f4c8adb12f3d6ae1cfa
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754094B2

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