Tetrabutylammonium Fluoride → (3-pyrrolidin-1-ylphenyl)methanol

HRID 406388노트

반응식

HRID 406388 반응식
[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Si]([O:26][CH2:27][C:28]1[CH:29]=[C:30]([N:34]2[CH2:38][CH2:37][CH2:36][CH2:35]2)[CH:31]=[CH:32][CH:33]=1)(C(C)(C)C)(C)C>C1COCC1>[N:34]1([C:30]2[CH:29]=[C:28]([CH2:27][OH:26])[CH:33]=[CH:32][CH:31]=2)[CH2:38][CH2:37][CH2:36][CH2:35]1

참가 물질

4

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 66618917HCID 66618917, 화합물

생성물 1

HCID 7162062(3-pyrrolidin-1-ylphenyl)methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Tetrabutylammonium fluoride (1.0 M solution in THF, 3.8 ml) was added to a solution of 1-[3-(tert-butyldimethylsilyloxymethyl)phenyl]pyrrolidine in THF (20 ml) and the mixture was stirred at room temperature for 3.5 hours. The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography to obtain the title compound (557 mg).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-64db9458e0cf4711a293e8a8f1c1930e
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754100B2

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