Benzoic acid, 3-nitro-4-(1-piperidinyl)-, methyl ester → methyl 3-amino-4-piperidin-1-ylbenzoate

HRID 406392노트

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HRID 406392 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[N:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:7]([O:9][CH3:10])=[O:8])([O-])=O>CO.[C].[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[N:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:7]([O:9][CH3:10])=[O:8]

참가 물질

4

반응물 1

HCID 2878938Benzoic acid, 3-nitro-4-(1-piperidinyl)-, methyl ester

생성물 1

HCID 1250441methyl 3-amino-4-piperidin-1-ylbenzoate수율 85.2%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

Using 10% palladium carbon cartridge, a solution of methyl 3-nitro-4-(piperidin-1-yl)benzoate (3.07 g) in methanol (50 ml) was pumped through the H-Cube™ reactor (ThalesNano Inc.). After all the reaction mixture had passed through the H-Cube™ reactor, the reaction mixture was concentrated under reduced pressure. The residue was purified by NH-silica gel column chromatography to obtain a title compound (2.32 g).

후처리

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customThe residue was purified by NH-silica gel column chromatography

출처 및 근거

ORD 기록
ord-499299740561403c805c413cc3cb0f8b
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754100B2

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