Benzamide → 2-(3-fluorophenyl)-7-methoxy-8-methyl-1H-quinazolin-4-one

반응식

[NH2:1][C:2]1[C:10]([CH3:11])=[C:9]([O:12][CH3:13])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].C(N)(=O)C1C=CC=CC=1.[F:23][C:24]1[CH:25]=[C:26]([CH:30]=[CH:31][CH:32]=1)[C:27](Cl)=O>>[F:23][C:24]1[CH:25]=[C:26]([C:27]2[N:6]=[C:4]([OH:5])[C:3]3[C:2](=[C:10]([CH3:11])[C:9]([O:12][CH3:13])=[CH:8][CH:7]=3)[N:1]=2)[CH:30]=[CH:31][CH:32]=1

참가 물질

반응물 3

HCID 2331Benzamide

HCID 743763-Fluorobenzoyl chloride

HCID 591654352-Amino-4-methoxy-3-methylbenzamide

생성물 1

HCID 1784877302-(3-fluorophenyl)-7-methoxy-8-methyl-1H-quinazolin-4-one수율 73%

실험 절차

The general procedure described in Example 10 was followed using 2-amino-4-methoxy-3-methyl benzamide as benzamide derivative [A] and 3-fluoro-benzoyl chloride as acid chloride [B], which gave the title compound (2.1 g, 73%), [M+H]=271.

출처 및 근거

ORD 기록: ord-8e2d63587aea424ea929e58fb10092f9
출처 데이터셋: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08754105B2

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