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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 406456생성일: 2026년 10월 26일

Halauxifen-methyl → Methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate

https://huagongshe.com/reaction/406456

반응식

참여 물질

역할이름HCID투입량
반응물Halauxifen-methylHCID 16656802—
반응물Methyl 4-acetamido-3,6-dichloropyridine-2-carboxylateHCID 22677481—
생성물Methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylateHCID 67210962—

반응 단계

Methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate is produced from a 4-chloro-2-fluoro-3-substituted-phenylboronic acid derivative, such as PBA. As shown in the reaction scheme below, the methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate (Compound 1) is produced by reacting PBA (Compound 2) with methyl 4-(acetylamino)-3,6-dichloropyridine-2-carboxylate (Compound 3) to produce methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate (Compound 4), which is deacetylated to produce Compound 1:

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08754110B2
출처 데이터셋uspto-grants-2014_06
ORD IDord-cb2f188a09144ffcb0784a37bcc4f99a
출처 메모uspto-grants-2014_06