Water → 1-(4-Bromophenyl)-4-(methylsulfonyl)piperazine

HRID 40694노트

반응식

HRID 40694 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23].O>ClCCl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][N:11]([S:22]([CH3:21])(=[O:24])=[O:23])[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 27356291-(4-Bromophenyl)piperazine

생성물 1

HCID 219193841-(4-Bromophenyl)-4-(methylsulfonyl)piperazine수율 99.9%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1-(4-Bromophenyl)piperazine (5 g, 20.7 mmol) is placed in 104 ml of dichloromethane and then triethylamine (4.34 ml, 31.1 mmol) is added, followed, dropwise, by methanesulfonyl chloride (1.93 ml, 24.9 mmol). Stirring is maintained for 16 h. After the addition of 30 ml of water and stirring, the organic phase is washed with a saturated aqueous sodium chloride solution, dried over MgSO4 and concentrated. 6.6 g of expected 1-(4-bromophenyl)-4-methanesulfonylpiperazine are obtained.

후처리

  1. temperatureis maintained for 16 h
  2. stirringstirring
  3. washthe organic phase is washed with a saturated aqueous sodium chloride solution
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-bb724b676d6c4ddc89c7c0ee5d97c752
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530477B2

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