Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 406942생성일: 2026년 10월 25일
Hydrogen Bromide → (2R,4aR,10bR)-6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydro-phenanthridin-2-ol hydrobromide
https://huagongshe.com/reaction/406942
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | (2R,4aR,10bR)-6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydro-phenanthridin-2-ol | HCID 11258441 | — |
| 용매 | Methyl Isobutyl Ketone | HCID 7909 | — |
| 생성물 | (2R,4aR,10bR)-6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydro-phenanthridin-2-ol hydrobromide | HCID 67022669 | 97% |
반응 단계
(2R,4aR,10bR)-6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydro-phenanthridin-2-ol (1.2 g; 2.9 mmol) is dissolved in 7.2 ml of 4-methyl-2-pentanone. The solution is heated up to 60° C. 350 μl (3.05 mmol) of aqueous HBr (W=47%) are added. After crystallisation the suspension is stirred over night. The crystals are filtered off and dried to obtain 1.38 g (97%) of the title compound (m.p.: 163° C.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08754218B2 |
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| 출처 데이터셋 | uspto-grants-2014_06 |
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| ORD ID | ord-a8cd826a849c4e509d6f6f90ee3790e1 |
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| 출처 메모 | uspto-grants-2014_06 |
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