Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 406947생성일: 2026년 10월 24일
1,2-Ethanedisulfonic Acid → (2R,4aR,10bR)-6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a, 10b-hexahydro-phenanthridin-2-ol ethandisulfonate
https://huagongshe.com/ko/reaction/406947
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,2-Ethanedisulfonic Acid | HCID 8032 | — |
| 반응물 | (2R,4aR,10bR)-6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydro-phenanthridin-2-ol | HCID 11258441 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (2R,4aR,10bR)-6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a, 10b-hexahydro-phenanthridin-2-ol ethandisulfonate | HCID 11855285 | 77.2% |
반응 단계
(2R,4aR,10bR)-6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydro-phenanthridin-2-ol (1.2 g; 2.9 mmol) is dissolved in 8.2 ml of tetrahydrofuran. The solution is heated up to 50° C. 580 mg (3.05 mmol) of ethandisulfonic acid are added. After crystallisation 1 ml ethanol is added and the suspension is stirred over night. The crystals are filtered off and dried to obtain 1.35 g (77%) of the title compound (m.p.: 233° C.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08754218B2 |
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| 출처 데이터셋 | uspto-grants-2014_06 |
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| ORD ID | ord-7f17083cf7d3437eb80d72f67268327e |
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| 출처 메모 | uspto-grants-2014_06 |
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