돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 407057생성일: 2026년 10월 25일

1-Cyanocyclopropanecarboxylic acid → N-[3-(7-{1-[1-[(1-Cyanocyclopropyl)carbonyl]-3-(cyanomethyl)azetidin-3-yl]-1H-pyrazol-4-yl}imidazo[1,2-b]pyridazin-3-yl)phenyl]-N'-(2,2,2-trifluoroethyl)urea

https://huagongshe.com/reaction/407057

반응식

참여 물질

역할이름HCID투입량
반응물1-Cyanocyclopropanecarboxylic acidHCID 2733259—
반응물N-[3-(7-{1-[3-(cyanomethyl)azetidin-3-yl]-1H-pyrazol-4-yl]imidazo[1,2-b]pyridazin-3-yl)phenyl]-N'-(2,2,2-trifluoroethyl)ureaHCID 67980375—
생성물N-[3-(7-{1-[1-[(1-Cyanocyclopropyl)carbonyl]-3-(cyanomethyl)azetidin-3-yl]-1H-pyrazol-4-yl}imidazo[1,2-b]pyridazin-3-yl)phenyl]-N'-(2,2,2-trifluoroethyl)ureaHCID 57386161—

반응 단계

This compound was prepared by using procedures analogous to those described for the synthesis of Example 77 starting from N-[3-(7-{1-[3-(cyanomethyl)azetidin-3-yl]-1H-pyrazol-4-yl}imidazo[1,2-b]pyridazin-3-yl)phenyl]-N′-(2,2,2-trifluoroethyl)urea and 1-cyanocyclopropanecarboxylic acid. LCMS (M+H)+: m/z=589.2.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08754114B2
출처 데이터셋uspto-grants-2014_06
ORD IDord-add1c920ac3a48d8bae2fc7064d5c26a
출처 메모uspto-grants-2014_06