Acetic Acid → 4-Amino-2-fluorobenzoic acid

HRID 407285

반응식

HRID 407285 반응식
[F:1][C:2]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C(O)(=O)C>[Pd].CO>[NH2:11][C:9]1[CH:8]=[CH:7][C:3]([C:4]([OH:6])=[O:5])=[C:2]([F:1])[CH:10]=1

참가 물질

5

반응물 2

HCID 176Acetic AcidHCID 3026792-Fluoro-4-nitrobenzoic acid

생성물 1

HCID 3026804-Amino-2-fluorobenzoic acid수율 102.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 2-fluoro-4-nitrobenzoic acid (1.0 g, 5.4 mmol) in 20 mL of a mixture of acetic acid and methanol (1:1), was added a catalytic amount of palladium on charcoal (25 mg). The reaction was stirred under an atmosphere of hydrogen gas at room temperature overnight. The mixture was then filtered through celite and the solvent was removed by evaporation to yield 0.86 g (100%) of the title compound as a cream coloured solid.

후처리

  1. filtrationThe mixture was then filtered through celite
  2. customthe solvent was removed by evaporation

출처 및 근거

ORD 기록
ord-f70d0418ffcb4c2ca79700e34c3bd20b
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754233B2

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