Water → Benzenesulfonamide, 4-chloro-N-methyl-3-nitro-

HRID 407298

반응식

HRID 407298 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[CH3:15][NH2:16].O>C1COCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:16][CH3:15])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13]

참가 물질

5

반응물 3

HCID 962WaterHCID 6329MethylamineHCID 7323Benzenesulfonyl chloride, 4-chloro-3-nitro-

생성물 1

HCID 67301Benzenesulfonamide, 4-chloro-N-methyl-3-nitro-

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 4-chloro-3-nitrobenzenesulfonyl chloride (2.0 g, 7.8 mmol) in THF (10 mL) was added excess methylamine (2M solution in THF). The reaction solution was stirred at room temperature for 1 hr. Water was then added and the product was extracted into chloroform. The combined extracts were washed, dried over sodium sulfate, filtered and evaporation to yield 2.3 g of the crude 4-chloro-N-methyl-3-nitrobenzenesulfonamide as an oil. The crude material was used in the subsequent step without further purification.

후처리

  1. extractionthe product was extracted into chloroform
  2. washThe combined extracts were washed
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. customevaporation

출처 및 근거

ORD 기록
ord-7e66ffe243c542b88debab339a8b946d
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754233B2

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