Morpholine → 2-[2-(morpholine-4-sulfonyl)ethyl]-2,3-dihydro-1H-isoindole-1,3-dione

HRID 40758

반응식

HRID 40758 반응식
[C:1]1(=[O:17])[N:5]([CH2:6][CH2:7][S:8](Cl)(=[O:10])=[O:9])[C:4](=[O:12])[C:3]2=[CH:13][CH:14]=[CH:15][CH:16]=[C:2]12.[NH:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1>>[O:21]1[CH2:22][CH2:23][N:18]([S:8]([CH2:7][CH2:6][N:5]2[C:4](=[O:12])[C:3]3[C:2](=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:1]2=[O:17])(=[O:10])=[O:9])[CH2:19][CH2:20]1

참가 물질

3

반응물 2

HCID 8083MorpholineHCID 3087392-Phthalimidoethanesulfonyl chloride

생성물 1

HCID 174221002-[2-(morpholine-4-sulfonyl)ethyl]-2,3-dihydro-1H-isoindole-1,3-dione

실험 절차

Prepared according to general method A from 2-phthalimidoethanesulfonyl chloride (2.0 g) and morpholine (2.14 ml). Yield: 1.28 g (48%). 1H-NMR (CDCl3) δ (ppm) 7.94-7.84 (m, 4H), 3.99 (t, J=6.8 Hz, 2H), 3.62 (t, J=4.7 Hz, 4H), 3.45 (t, J=6.8 Hz, 4H), 3.15 (t, J=4.6 Hz, 4H).

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-cf4e3b74584149aeb41b3c78b6d7da5f
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530486B2

연결된 노트

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